Holden Karnofsky is the co-CEO of Open Philanthropy and co-founder of GiveWell. He is also the author of one of the most interesting blogs on the internet, Cold Takes. We discuss: * Are we living in the most important century? * Does he regret OpenPhil’s 30 million dollar grant to OpenAI in 2016? * How does he think about AI, progress, digital people, & ethics? Highly recommend! Watch on YouTube. Listen on Apple Podcasts, Spotify, or any other podcast platform. Read the full transcript here. Timestamps (0:00:00) - Intro (0:00:58) - The Most Important Century (0:06:44) - The Weirdness of Our Time (0:21:20) - The Industrial Revolution (0:35:40) - AI Success Scenario (0:52:36) - Competition, Innovation , & AGI Bottlenecks (1:00:14) - Lock-in & Weak Points (1:06:04) - Predicting the Future (1:20:40) - Choosing Which Problem To Solve (1:26:56) - $30M OpenAI Investment (1:30:22) - Future Proof Ethics (1:37:28) - Integrity vs Utilitarianism (1:40:46) - Bayesian Mindset & Governance (1:46:56) - Career Advice Get full access to Dwarkesh Podcast at www.dwarkeshpatel.com/subscribe